Prehypertension is a part of the continuum from normotension to hypertension it is a part of a dynamic process of stiffening and aging of the arteries and of the heart with its consequences. Patients in the prehypertensive range will become finally hypertensive. Diseased arteries will not only participate in propagation of end organ damage but will enhance the progression of additional damage in the arteries and the heart. Understanding the risk of borderline conditions in the metabolic syndrome will enable us to understand the nature of end organ damage and will create a possibility of better prevention of this continuous process.Hypertension, Diabetes, Dyslipidemia and Obesity are considered as major risk factors for Atherosclerosis of cerebral, coronary and peripheral arteries. This process causes Development of Ischemic heart disease, obstruction to cerebral flow and PVD. Clustering of these risk factors is very common and their accumulation causes faster propagation of end organ damage and cerebrovascular events. The diagnosis of risk factors, especially when they are clustered, justify multidisciplinary aggressive therapeutic approach which should be started as soon as possible with diagnosis.The Conference will aim to deal with all aspects related to early diagnosis, including innovative technologies and treatments as well as discussion of target organ damage, cardiac, renal, neurological and peripheral arteries. The conference will bring together professionals from the fields of Hypertension, Cardiology, Nephrology, Endocrinology, Internal Medicine and more.We hope that you will join us for what promises to be a stimulating professional and educational event and look forward to welcoming you to Vilnius. ChairmanRimvydas Slapikas and Reuven Zimlichman Honorary Chairman Giuseppe Mancia and Stevo Julius. URL:Tickets: https://go.evvnt.com/240263-1?pid=5569 Time: 8:00 am to 5:00 pm. Venue details: Radison Blu Hotel, Konstitucijos pr. 20, Vilnius, 09308, Lithuania. Price:Early Bird Registration: EUR 550.0. Speakers: Rimvydas Slapikas, Reuven Zimlichman, Stevo Julius, Giuseppe Mancia, Enrico Agabiti-Rosei, Daniel A Duprez, Hermann Haller, Marius Miglinas, Gianfranco Parati, Gintare Sakalyte, Remigijus Zaliunas, Inga Bumblyte, Aleksandras Laucevicius, Daiva Rastenyte, Rimvyds Slapikas, Rasa Verkauskiene, Marcin Adamczak, Giuseppe Ambrosio, Maciej Banach, Johannes Baulman, Jack Blacher, Mona Boaz, Pierre Boutouryie, Marianne Brodmann, Michael Bursztyn, Renata Cifkova, John R. Cockcroft, Francesco Cosentino, Cesare Cuspidi, Danuta Czarnecka, Leszek Czupryniak, Peter W. de Leeuw, Mahfouz El Shahawy, Raimund Erbel, Andris Erglis, Cetin Erol, Michel Farnier, Csaba Farsang, Flavio D. Fuchs, Sandra Fuchs, Dov Gavish, Guido Grassi, Janusz Gumprecht, Tomasz Guzik, Pavel Hamet, Anthony M. Heagerty, Dagmara Hering, Mohsen Ibrahim, Uday Jadhav, Andrzej Januszewicz, Bojan Jelakovic, Petr Kala, Sverre E. Kjeldsen, Stephane Laurent, Gustavs Latkovskis, John R. Lekakis, Bernard L. Levy, Basil S. Lewis, Mieczyslaw Litwin, Luigi Luliano, Athanasios Manolis, Carmel McEniery, Dimitri Mikhalidis, Branislav Milovanovic, Krzysztof Narkiewicz, Marek Naruszewicz, Peter M Nilsson, Salvatore Novo, Agnieszka Olszanecka, Paolo Palatini, Achille C. Pessina, Aleksander Prejbisz, Brian Rayner, Itamar Raz, Efrain Reisin, Manfredi Rizzo, Damiano Rizzoni, Enrique Rodilla Sala, Alexander R. Rosenkranz, Gian Paolo Rossi, Talma Rosenthal, Luis Ruilops, Guntram Schernthaner, Arno Schmidt – Trucksass, Sekib Sokolovic, Ljudmila Stojanovich, Katarzyna Stolarz-Skrzypek, Rhian Touyz, Stefano Taddei, Andrzej Tykarski, Thomas Unger, Panos Vardas, Margus Viigimaa, Charalambos Vlachopoulos, Bruno Watschinger, Thomas Weber, Krystyna Widecka, Andrzej Wiecek, Ian B. Wilkinson, Tomasz Zdrojewski, Yuqing Zhang.