Fulfilling the potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression of disease-relevant genes. RNA-based drugs and antisense nucleotides, are promising examples of a newer class of biologics. Researchers have tried to overcome the major challenges for utilising RNAs in a therapeutic context, including: intracellular delivery, stability and immunogenicity. Bringing together industry experts, to discuss the challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies and present an overview of the applications of RNA-based drugs for modulation of gene and protein expression and genome editing. KEYNOTE SPEAKERS• Ekkehard Leberer, Senior Director, Alliance Management, Sanofi• Shalini Andersson, Senior Director and Head of New Modalities, AstraZeneca• Carsten Rudolf, Chief Executive Officer, Ethris Gmbh• Paul Agris, Founder and Director, The RNA Institute• Marian Gindy, Executive Director, Pharmaceutical Sciences, Merck Research Labs, Merck and Co• David Giljohan, CEO, Exicure• Ingmar Hoerr, Founder and CEO, CureVac AG• David Blakey, Chief Scientific Officer, MiNA Therapeutics• André Gerber, Professor of RNA Biology, University of Surrey• Heinrich Haas, Vice President Drug Delivery, BioNTech RNA Pharmaceuticals• Markus Mandler, Chief Scientific Officer, Accanis Biotech• Troels Koch, Vice President and Head of Research, RNA Therapeutics, Roche• Hans Kistemaker, Associate Director, ProQR HIGHLIGHTS- Discover the clinical progress of Spherical Nucleic Acids- Understand Sanofi’s strategies to deliver therapeutic oligonucleotides across biobarriers- Learn from ProQR how to plan for oligonucleotide supply from personalized medicine to large scale markets- Explore the development of small activating RNA – from bench to bedside with MiNA Therapeutics- Gain insight into the discovery and development of self-amplifying mRNA vaccines at GSK Price:Standard Price (Early Bird Rates Available Online): GBP 1499.0. Time: 8:30 am to 5:00 pm. Venue details: Copthorne Tara Hotel London Kensington, Scarsdale Place, Greater London, W8 5SY, United Kingdom.