Biocatalysis: Solving Scale-Up Issues with Biocatalysed Reactions

Memo

This is online short course will look at biocatalysed/biotransformation reactions to make pharma/agrochem chem intermediates, API’s and fine chemicals. the focus is on scale-up issues and getting productive process established. June 17th, 1.30 – 4.30 pm (UK) | Session 1 June 18th, 1.30 – 4.30 pm (UK) | Session 2 Many forays by organic chemists into using biocatalysis in chemical synthesis stall at the initial scale-up stage. Screening and small scale (gram) reactions progress as planned, but when scaled -up, reactions stall, take more enzyme than expected, work-ups end up with emulsion issues etc. This course will look at some of the techniques and technologies ( tricks of the trade) that can help derisk scaling up biocatalysed reactions .A further barrier to the adoption of more biocatalytic reactions are production / EHS scientists who are unsure how to handle enzymes in the plant/pilot plant. the course will also look at good sources of information/data to facilitate the use of enzymes at scale. Enzyme supply chain: Storage, stability etcTechno-economic analysis – will the transformation ever hit the required targets?Different types of strains used and its safety impactions.Using GMO’s and GMO derived materialsHandling concerns related to enzyme -SHE/EHS issues., Safety issues in scaling up biocatalytic reactionsPros and cons of different enzyme formulationsEnzyme stability: General to pH, co-solvent, temperature as linked to process design and developmentEnzyme analysis / characterisation – needed to assess purity in order to calculate activity and so expected long term cost, spec setting / quality control (ensure plant samples match lab samples and measure variation over time).Scale-up – reactor options – various reactor types, std batch, continuous, membrane separated, continuous liquid extraction, etcProduct isolation from complex mix . Enzyme removal/ downstream processing– to be intelligent in terms of what can and can’t be removed vs effects on process including downstream chemistry.Use of immobilised enzymes/ Recycling of immobilised enzymesSome IP considerations   URL:Tickets: https://go.evvnt.com/2437076-0?pid=5569  Date and Time: On Mon, 17 Jun 2024 13:30 - Tue, 18 Jun 2024 16:30 Prices:General Admission: GBP 549.00,Hard Copy Manual: GBP 90.00 Speaker: Dr Andrew Wells