Natural products have the potential to solve global challenges in medicine, agriculture, energy and materials. We have only characterized and harnessed a fraction of this potential, and genome sequencing has revealed an enormous untapped biosynthetic capacity. Synthetic biology tools are being applied to translate this encoded diversity of biosynthetic pathways into their respective compounds; many of which are novel. AI is beginning to be applied to novel prediction and innovative design of natural products. The Synthetic Biology of Natural Products conference will integrate these disciplines with the goal of generating new platforms, tools, and technologies to capture, manipulate and engineer natural product genes and pathways. Converting this vast untapped genomic diversity into novel chemical leads for biomedical, bioproduct and agricultural applications will require breakthroughs in design, scale and biologics that currently limit the field.