
Synopsis Over the past two decades, breakthroughs in gastrointestinal (GI) stem cell biology have transformed our ability to identify, trace, and manipulate intestinal stem cells (ISCs). The field is now entering an exciting new phase: uncovering how dysregulated ISC behavior contributes to disease, and how GI disorders in turn affect stem cell function. The Fusion Intestinal Stem Cell Conference will bring together an international community of researchers and clinicians to share the latest advances. Discussions will highlight how the microenvironment of the esophagus, stomach, small intestine, and colon shapes stem cell dynamics in both health and disease, as well as how the niche varies across the GI tract. Attendees will also explore cutting-edge experimental models for investigating the relationship between ISCs, their niche, and disease initiation and progression. Key Sessions • Inflammation: causes and consequences• Microbiome and inter-tissue signaling• Metabolism and aging• In vitro modelling of the GI tract• GI diseases and stem cells• Cellular plasticity in the GI tract• Regulation of ISC behavior