The conference will bring together scientists working to better understand nuclear and genome organisation in various organisms, tissues, and cell states. Conference sessions will cover topics related to:● Nuclear and subnuclear structure and function● Nuclear organisation and chromosome topology in gene expression● Nuclear organisation and chromosome topology in DNA replication and repair● Crosstalk between transcription and repair● Impact of nuclear and genome organisation on genome editing● Genome editing technologies in the study of nuclear and genome structure and function● Nuclear bodies including the nucleolus, Cajal bodies, speckles, PML bodies● Constitutive and induced phase separation in the nucleus● Topologically associated domains and transcription in genome control● Signalling cues, cellular states and genome organisation● Genome organisation in pluripotency and during differentiation● Nuclear and genome structures in health, cancer, aging, and age-related diseases● Chromatin loops and non-canonical nucleic acids structures in genome expression and stability● Spatial genome organisation: from the bench to the bedside Workshops will cover: Technical advances in the study of nuclear and genome organisation; The next frontiers in spatial genome organisation and its connection to health and disease; How to publish in the era of spatial genome organisation?