The conference program covers how RNA and RNA-dependent machineries govern chromatin landscape, gene expression, and genome architecture during development, homeostasis, and in response to cellular stress. This conference prioritises high-throughput and systems biology approaches that convey new mechanistic insights into genome regulation and will also highlight emerging methods/technology that will propel the field forward in the coming years. This conference provides a platform for cross-fertilization between a heterogeneous set of scientific communities encompassing RNA biology, epigenetics, DNA repair, transcription, genetics, and genome engineering.