Fibroblast Growth Factor Signalling in Development, Health & Disease Conference

Memo

Receptor Tyrosine Kinases (RTKs) are cell-surface receptors that, upon ligand binding, regulate cell-to-cell communication during embryonic development and in adult life. Among RTKs, the twenty-two Fibroblast Growth Factors (FGFs) and five FGF Receptors play crucial roles in proliferation, migration, differentiation, and metabolism. Aberrant FGF signalling underlies genetic and metabolic disorders, age-related diseases, and cancer. Advances in structural biology, omics technologies, and disease models as well as very promising clinical trials have greatly facilitated our understanding of FGF functions. However, many outstanding questions remain unanswered, including how FGFs interact with other signaling pathways to regulate the specificity of cellular responses in development, health, and disease. Key Sessions Frontiers in FGF Signalling Regulation New Technologies to Study Cell Signalling FGF Signalling in Development and Adult Homeostasis Signalling Underlying FGF-driven Genetic and Age-related Diseases FGF Signalling in Tissue Regeneration and Stem Cells FGF Signalling in Metabolic Diseases Molecular Mechanisms of FGF Signalling in Cancer Targeting the FGF-FGFR Axis in Translational Research  Past, Present and Future of Cell Signalling