5th Epigenetics From Mechanisms to Therapies Conference

Memo

Our ability to read, interpret and manipulate the genome has entered an era defined by single-cell resolution, 3D chromatin organization, and the integration of cell-intrinsic gene regulation, metabolic inputs and environmental challenges with human disease biology. Epigenetic mechanisms - considered as the “regulators of the regulators” - sit at the centre of efforts to understand development, aging and the molecular origins of disease. At the same time, the boundaries between chromatin biology, nuclear metabolism, transcriptional regulation, stem cell and cancer biology have largely dissolved. Modern research demands a fully integrated perspective. The 5th Epigenetics: From Mechanisms to Therapies meeting will bring together leading scientists driving this transformation. This edition will highlight how chromatin organisation, nuclear architecture, gene regulatory networks, metabolism and RNA-based mechanisms converge to shape cell identity and plasticity across development, homeostasis and disease. A major focus will be placed on single-cell and spatial genomics, cutting-edge epigenomic technologies and new cellular models, as well as on epigenetic mechanisms modulating cancer, neurodevelopmental and neurological diseases.