4th Ubiquitin Function in Health & Disease Conference

Memo

Our understanding of the ubiquitin system is at a transformative moment – we are beginning to unravel its function in connection to its physiological roles with profound implications for many severe diseases. Initially discovered as a tag of cytosolic proteins for proteasomal degradation, the ubiquitin system is now recognized as a master regulator of cellular signaling, well beyond protein turnover. Ubiquitination and its reversal by deubiquitination provide dynamic control over a vast array of signaling pathways, enabling cells to finely tune the intensity and duration of signaling responses.While some signaling roles are indeed related to ubiquitin’s degradative capacity – such as the activation of the transcriptional master regulator of inflammation, NF-κB, via degradation of its inhibitor IκB – most signaling-related functions of the ubiquitin system depend on non-degradative ubiquitin chains. These chains act as scaffolds, enabling the assembly of highly specific protein complexes that first initiate, then propagate and, finally, terminate crucial pathways of cellular signaling.This conference shifts the spotlight from structural details to biological function. Together, we shall explore how the ubiquitin system orchestrates signal transduction under physiological conditions, what happens when this regulation breaks down and how this knowledge can be harnessed to develop a new generation of exquisitely specific and highly effective medicines. From cancer and chronic inflammation to autoimmune and neurodegenerative diseases, the therapeutic potential of targeting the ubiquitin system is near endless.